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  1. 1.METHOD OF ANALYZING STRUCTURE OF SUGAR CHAIN

  2. Publication date: 2007-07-25

  3. Inventor(s): KANIE OSAMU; KURIMOTO AYAKO; DAIKOKU SYUSAKU

  4. Applicant(s): MITSUBISHI CHEM CORP

  5. Abstract of  EP 1811294  (A1)

  6. It is an objective of the present invention to provide a method of analyzing the structure of a sugar chain by performing CID-MSn measurement of a sugar chain of unknown structure and comparing the obtained data with obtained reference data acquired in advance.


  7. 2.METHOD FOR PRODUCTION OF 3-FLUOROSIALIC ACID DERIVATIVE HAVING alpha-GLYCOSIDE LINKAGE

  8. Publication date:  2007-03-15

  9. Inventor(s): SUGANO KAZUAKI; YONEYAMA TAKAHIRO; KANIE OSAMU

  10. Applicant(s): MITSUBISHI CHEM CORP

  11. Abstract of  JP 2007063262  (A)

  12. PROBLEM TO BE SOLVED: To provide a method for efficiently producing a 3-fluorosialic acid derivative having an [alpha]-glycoside linkage.

  13. SOLUTION: The production method for the 3-fluorosialic acid derivative having the [alpha]-glycoside linkage comprises the replacement reaction of the siloxy group of [alpha]-2-siloxy-3-fluorosialic acid derivative protected by a benzyl group with a compound represented by X-R (wherein X is a leaving group, and R is an organic group). ; COPYRIGHT: (C)2007,JPO&INPIT


  14. 3.METHOD OF SYNTHESIZING SUGAR CHAIN

  15. Publication date:  2006-03-29

  16. Inventor(s): KANIE OSAMU

  17. Applicant(s): MITSUBISHI CHEM CORP

  18. Abstract of  EP 1640379  (A1)

  19. An object of the present invention is to provide a method for efficiently chemically synthesizing biomolecules including a nucleotide (nucleic acid), a peptide (protein), or a sugar chain, as representative examples. The present invention provides a method of solid-phase synthesis of sugar chain(s) for synthesizing multiple types of sugar chains in at least one sugar chain synthesis reaction system comprising multiple types of monosaccharide units, which is characterized in that it comprises changing the temperature in the sugar chain synthesis reaction system depending on the temperature rising rate that has been determined based on a decrease in side reaction(s) in the reaction system as an indicator.


  20. 4.AUTOMATIC SOLID PHASE SYNTHESIZING APPARATUS

  21. Publication date:  2005-10-27

  22. Inventor(s): KAYOU ATSUSHI; KOSHIHATA MASANOBU; KANIE OSAMU; NISHINO MITSUAKI

  23. Applicant(s): MITSUBISHI CHEM CORP

  24. Abstract of  JP 2005296832  (A)

  25. PROBLEM TO BE SOLVED: To provide an automatic solid phase synthesizing apparatus not using an excess reagent from the viewpoint of resource conservation and energy saving and requiring no power means of a stirring and mixing.

  26. SOLUTION: The automatic solid phase synthesizing apparatus includes a keeping container of a plurality of reaction reagents and solvents for performing synthetic reaction, piping for supplying the reaction reagents and the solvents to a fine tubular reaction pipe, a liquid feed means for feeding the reaction reagents and the solvents to the fine tubular reaction pipe, a changeover valve for supplying only the desired reaction reagent and the solvent to the fine tubular reactor and a fine tubular reactor filled with a reactive substrate fixing carrier. After a necessary amount of the reaction reagent is fed into the fine tubular reactor, desired synthesizing reaction is performed in a state that the feed of the reaction reagent is stopped. After the completion of reaction, the reaction reagent other than the reaction product fixed to a carrier is washed off by the solvent. ; COPYRIGHT: (C)2006,JPO&NCIPI


  27. 5.AZASUGAR COMPOUNDS

  28. Publication date:  2003-01-30

  29. Inventor(s): KANIE OSAMU; SAOTOME CHIKAKO

  30. Applicant(s): MITSUBISHI CHEM CORP; KANIE OSAMU; SAOTOME CHIKAKO

  31. Abstract of  WO 03008379  (A1)

  32. Compounds represented by the general formula (I) or salts thereof: (I) [wherein R1 is hydrogen, optionally substituted C1-C10 alkyl, or an N-protecting group; R2 is optionally substituted C1-C10 alkyl or optionally substituted C2-C10 alkenyl; R3 and R4 are each independently hydrogen or a hydroxyl-protecting group; X is -N(R5)R6 or a residue derived from the amino group of an amino acid or a peptide (wherein R5 and R6 are each independently hydrogen, optionally substituted C1-C10 alkyl, or optionally substituted C3-C12 cycloalkyl); and Y is hydrogen, -CH2NH2, -CONH2, or -COOH]. The compounds are useful as specific inhibitors against sugar chain related enzymes including glycosyltransferase and glycosidase, and effective in treatment or prevention of diseases in which sugar chain related enzymes participate.


  33. 6.METHOD FOR ANALYZING ENZYME REACTION

  34. Inventor(s):  KANIE OSAMU; KANIE YOSHIMI

  35. Applicant(s): MITSUBISHI CHEM CORP

  36. Publication date:  2003-10-21

  37. Abstract of  JP 2003299499  (A)

  38. PROBLEM TO BE SOLVED: To achieve the analysis of the reaction of a trace of an enzyme with a substrate by analyzing the enzyme reaction by carrying out the reaction of a polyhydroxy compound such as a sugar chain with the enzyme using the compound as a substrate, and the separation of the reaction product by using a capillary electrophoresis.

  39. SOLUTION: The method for analyzing the enzyme reaction using the polyhydroxy compound as the substrate comprises injecting each of the enzyme using the polyhydroxy compound dissolved in a biochemically usable buffer as the substrate, and the substrate for the enzyme into a capillary, and carrying out the enzyme reaction and the separation of the reaction product by the capillary electrophoresis using a buffer forming a complex with the polyhydroxy group. ; COPYRIGHT: (C)2004,JPO


  40. 7.MEDICAMENT CONTAINING SIALIC ACID DERIVATIVE AS ACTIVE COMPONENT 

  41. Publication date:  2001-05-15

  42. Inventor(s): KANIE OSAMU; CHI-WAY WONG; SUZUKI YASUO

  43. Applicant(s): RIKAGAKU KENKYUSHO

  44. Abstract of  JP 2001131074  (A)

  45. PROBLEM TO BE SOLVED: To provide new medicaments comprising a sialic acid derivative, especially a low-molecular sialic acid derivative, and more concretely to provide a prophylactic and/or therapeutic agent for viral disease such as influenza virus infection disease. SOLUTION: The medicaments comprise a compound represented by formula I wherein R1 is a 1-6C alkyl group; R2 is a (substituted) phenyl group, a 1-20C alkyl group, a 1-20C alkenyl group or (CH2)k-[NH-(CH2)m-NH]n-Y (wherein Y is phoshatidyl ethanolamine residue, polyglutamic acid residue or the like; k and m are each an integer of 2 to 10); R3 is H or a (substituted) hydroxy group; R4 is H, a halogen, azido group, a (substituted) amino group or a (substituted) hydroxy group; and R5 to R8 are each a (substituted) hydroxy group} or its pharmacologically permissive salt as an active component.


  46. 8.POLYMER COMPOUND CONTAINING SACCHARIDE-BONDED SPHINGOSINE

  47. Publication date:  1999-06-02

  48. Inventor(s): KANIE OSAMU; CHI-WAY WONG; KAMITAKAHARA HIROSHI

  49. Applicant(s): RIKAGAKU KENKYUSHO

  50. Abstract of  JP 11147951  (A)

  51. PROBLEM TO BE SOLVED: To obtain a polymer compound or its salt which can exhibit antiviral action on various types of viruses and being useful as an active ingredient of medicines, which comprises a biodegradable polymer containing sphingo glycolipid.

  52. SOLUTION: There are provided a polymer compound in which the sphingo glycolipid is desirably lysosphingo glycolipid, more desirably lysoganglioside, particularly desirably lysoganglioside GM12 or a salt thereof: a polymer compound prepared by bonding sphingo glycolipid to a biodegradable polymer through a spacer or a salt thereof; and a polymer compound in which the biodegradable polymer is polyglutamic acid, more desirably an N-terminal acetylated polyglutamic acid or a salt thereof. The salts are desirably sodium salts. A polymer compound of the formula (wherein R1 is H or acetyl; R2 is H or a fluorescent functional group; and (m) and (n) are each 10-40) or a salt thereof is the most desirable.


  53. 9.SIALIC ACID DERIVATIVE

  54. Inventor(s):  CHI-WAY WONG; KANIE OSAMU; SON GAKURYU

  55. Applicant(s): RIKAGAKU KENKYUSHO

  56. Publication date:  1999-12-14

  57. Abstract of  JP 11343295  (A)

  58. PROBLEM TO BE SOLVED: To obtain a sialic acid derivative useful as an antiviral, capable of showing strongly inhibitory actions on sialidase being a membrane protein of influenza virus and on hemagglutinin.

  59. SOLUTION: This compound is shown by formula I [R1 is H or a 1-6C alkyl; R2 is a (substituted) phenyl, a 1-20C alkyl or the like; R3 is H or a (substituted) OH; R4 is H, a halogen or the like; R5 to R8 are each a (substituted) OH; Ac is acetyl; with the proviso that R3 and R4 are not H at the same time] such as methyl(p-nitrophenyl 5-acetamide-4,7,8,9-tetra-O-acetamide-5-deoxy-α-D-erythro-L-gluco-2-nonulopyranosido)nate.; The compound of formula I is obtained, in the case of the exemplified compound, by reacting a glucosyl bromide of formula II (Me is methyl) with sodium p-nitrophenoxide in a solvent such as N,N- dimethylformamide, for example, at a room temperature for 12 hours.


  60. 10.PROCESS FOR THE PREPARATION OF OLIGOSACCHARIDE MIXTURES

  61. Inventor(s):  HINDSGAUL OLE; KANIE OSAMU; PALCIC MONICA; ERNST BEAT

  62. Applicant(s): CIBA GEIGY AG; HINDSGAUL OLE; KANIE OSAMU; PALCIC MONICA; ERNST BEAT

  63. Publication date:  1996-02-29

  64. Abstract of  WO 9606102  (A1)

  65. The present invention relates to oligosaccharide mixtures whose individual constituents have an identical core structure which is substituted by at least one sugar and in which all positional isomers are represented, and all isomers with respect to the substituent are in the form of alpha - or beta -isomers, to a process for the preparation of said oligosaccharide mixture and to a process for the rapid isolation of a biologically active oligosaccharide.

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