Works carried out at MITILS (2000—2009)

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  1. 1.Analysis of a series of isomeric oligosaccharides based on energy-resolved mass spectrometry: A challenge on homobranched trisaccharides.

  2. Daikoku, S. Widmalm, G. Kanie, O.

  3. Rapid Commun. Mass Spectrom. 2009, 23, 3713-3719.

  4. 2.Microfluidic device enabling synthesis of a tetrasaccharide aiming at “Golgi Simulator”.

  5. Ono, Y. Daikoku, S. Hasegawa, Y. Sato, T. Kobayashi, M. Suzuki, K. Kanie, O.

  6. Molecular Imaging for Integrated Medical Therapy and Drug Development, Springer, Eds. Tamaki, N. Kuge, Y.,  2009, pp288-293. <Proceedings>

  7. 3.N-n-Hexyl-4-aminobutyl glycosides in the structural and biological investigations of oligosaccharide.

  8. Suzuki, K. Tobe, A. Adachi, S. Daikoku, S. Hasegawa, Y. Shioiri, Y. Kobayashi, M.  Kanie, O.

  9. Org. Biomol. Chem. 2009, 7, 4726-4733. DOI: 10.1039/b909556j

  10. 4.Analysis of behavior of sodiated sugar hemiacetals under low-energy collision-induced dissociation conditions and application to investigating mutarotation and mechanism of a glycosidase.

  11. Kanie, O, Kurimoto, A. Daikoku, S. Mutsuga, S. Kanie, Y. Suzuki, K.

  12. Proc. Jpn Acad. Ser. B, 2009, 85, 204-215.

  13. With Cover illustration!>>.

  14. 5.Insight into the regulation of glycan synthesis in Drosophila chaoptin based on mass spectrometry.

  15. Kanie, Y. Yamamoto-Hino, M. Karino, Y. Yokozawa, H. Nishihara, S. Ueda, R. M. Goto, S. Kanie, O.

  16. PLoS ONE, 2009, 4, e5434.


  18. 6.Capirally monolithic liquid chromatography-mass spectrometry of pyridylaminated oligosaccharides; Correlation of the data with Galaxy database.

  19. Kanie, Y. Kanie, O.

  20. J. Chromatogr. A, 2009, 1216, 4121-4124.

  21. 7.Ion-trap mass spectrometry unveils the presence of isomeric oligosaccharides in an analyte: Stage-discriminated correlation of energy-resolved mass spectrometry.

  22. Daikoku, S. Kurimoto, A. Mutuga, S. Ako, T. Kanemitsu, T. Shioiri, Y. Ohtake, A. Kato, R. Saotome, C. Ohtsuka, I. Koroghi, S. Sarkar, S. K. Tobe, A. Adachi, S. Suzuki, K. Kanie, O.

  23. Carbohydr. Res., 2009, 344, 384-394.

  24. 8.Energy-resolved structural details obtained from gangliosides.

  25. Shioiri, Y. Kurimoto, A. Ako, T. Daikoku, S. Ohtake, A. Ishida, H. Kiso, M. Suzuki, K. Kanie, O.

  26. Anal. Chem., 2009, 81, 139-145. 

  27. 9.3,4-Dihydroxypyrrolidine as glycosidase inhibitor.

  28. Suzuki, K. Nakahara, T. Kanie, O.

  29. Curr. Top. Med. Chem., 2009, 9, 34-57. <REVIEW>

  30. 10.Sequential enzymatic glycosyltransfer reactions on a microfluidic device: Synthesis of a glycosaminoglycan  linkage region tetrasaccharide.

  31. Ono, Y. Kitajima, M. Daikoku, S. Shiroya, T. Nishihara, S. Kanie, Y. Suzuki, K. Goto, S. Kanie, O.

  32. Lab. Chip., 2008, 8, 2168-2173.

  33. Selected as a “Hot Article.

  34. 11.N-Glycosylation of the Drosophila neural protein chaoptin is essential for its stability, cell surface transport and adhesive activity.

  35. Hirai-Fujita, Y. Yamamoto-Hino, M. Kanie, O. Goto, S.

  36. FEBS Lett., 2008, 582, 2572-2576.

  37. 12.Synthetic study of a glycosidase inhibitor with a new scaffold spirobicycloimidazoline.

  38. Nakahara, T. Okamoto, N. Suzuki, K. Kanie, O.

  39. Carbohydr. Res., 2008, 343, 1624-1635.

  40. 13.A mechanism of a novel gas-phase reaction via five-membered transition state: Dissociation reaction of 4-aminobutyl glycosides under CID MS/MS conditions.

  41. Shioiri, Y. Suzuki, K. Kanie, O.

  42. J. Mass Spectrom., 2008, 43, 1132-1139.

  43. 14.Comparative RP-HPLC for rapid identification of glycopeptides and application in off-line LC-MALDI-MS analysis.

  44. Kanie, Y. Enomoto, A. Goto, S. Kanie, O.

  45. Carbohydr. Res., 2008, 343, 758-768.

  46. Selected as Top 25 Hottest Articles.

  47. 15.Energy-resolved mass spectrometry (ERMS) of oligosaccharide.

  48. Kurimoto, A. Daikoku, S. Kanie, O.

  49. Experimental Glycoscience, Glycobiology, Springer, Ed. Taniguchi, N., 2008, 37-38. <Book chapter>

  50. 16.Stationary solid-phase reaction (SSPR) for oligosaccharide synthesis

  51. Ako, T. Kanie, O.

  52. Experimental Glycoscience, Glycobiology, Springer, Ed. Taniguchi, N., 2008, 164-165. <Book chapter>

  53. 17.High yielding and controlled dissociation of glycosides producing B- and C-ion species under CID MS/MS conditions and use in structure determination.

  54. Suzuki, K. Daikoku, S. Ako, T. Shioiri, Y. Kurimoto, A. Ohtake, A. Sarkar, S. K. Kanie, O.

  55. Anal. Chem., 2007, 79, 9022-9029.

  56. 18.Discrimination of 16 structural isomers of fucosyl galactose based on energy-resolved mass spectrometry (ERMS).

  57. Daikoku, S. Ako, T. Kato, R. Ohtsuka, I. Kanie, O.

  58. J. Am. Soc. Mass Spectrom., 2007, 18, 1873-1879.

  59. 19.Distinguishing isomeric pyridylaminated high-mannose (Man7) oligosaccharides based on energy-resolved mass spectra (ERMS).

  60. Kurimoto, A. Kanie, O.

  61. Rapid Commun. Mass Spectrom., 2007, 21, 2770-2778.

  62. 20.Anomeric information obtained from a series of synthetic trisaccharides using energy-resolved mass spectra.

  63. Daikoku, S. Ako, T. Kurimoto, A. Kanie, O.

  64. J. Mass Spectrom., 2007, 42, 714-723.

  65. 21.A method of orthogonal oligosaccharide synthesis leading to combinatorial library based on stationary solid-phase reaction.

  66. Ako, T. Daikoku, S. Ohtsuka, I. Kato, R. Kanie, O.
  67. Chem. Asian J., 2006, 1, 798-813.

  68. >>>With Cover Illustration!!!

  69. 22.Synthesis of a fucosyl galactose library consisting of a complete set of anomeric configurations and linkage positions.

  70. Ohtsuka, I. Ako, T. Kato, R. Daikoku, S. Koroghi, S. Kanemitsu, T. Kanie, O.

  71. Carbohydr. Res., 2006, 341, 1476-1487.

  72. 23.Orthogonal glycosylation reactions on solid-phase and the synthesis of a library consisting of a complete set of fucosyl galactose isomers.

  73. Kanie, O. Ohtsuka, I. Ako, T. Daikoku, S. Kanie, Y. Kato, R.

  74. Angew. Chem. Int. Ed., 2006, 45, 3851-3854.

  75. 24.Syntheses of model compounds related to an antigenic epitope in pectic polysaccharides from Bupleurum falcatum L. (II).

  76. Jin, Y. Hada, N. Oka, J. Kanie, O. Daikoku, S. Kanie, Y. Yamada, H. Takeda, T.

  77. Chem. Pharm. Bull. 2006, 54, 485-492.

  78. 25.Solid-phase synthesis of sialyl Tn antigen.

  79. Kanemitsu, T. Daikoku, S. Kanie, O.

  80. J. Carbohydr. Chem., 2006, 25, 361-376.

  81. 26.Analysis of energy-resolved mass spectra at MSn in a pursuit to characterize structural isomers of oligosaccharides.

  82. Kurimoto, A. Daikoku, S. Mutsuga, S. Kanie, O.

  83. Anal. Chem., 2006, 78, 3461-3466.

  84. 27.Single step multi-syntheses of glycosyl acceptors: Benzylation of n-1 hydroxyl groups of phenylthio glycosides of xylose, mannose, glucose, galactose, 2-azido-2-deoxy-glucose, and 2-azido-2-deoxy-galactose.

  85. Suzuki, K. Ohtsuka, I. Kanemitu, T. Ako T. Kanie, O.

  86. J. Carbohydr. Chem., 2005, 24, 219-236.

  87. 28.Synthetic alpha-mannosyl ceramide as a potent stimulant for a novel NKT cell repertoire bearing the invariant Va19-Ja26 TCR alpha chain.

  88. Okamoto, N. Kanie, O. Huang, Y.-Y. Fujii, F. Watanabe, H. Shimamura, M.

  89. Chem. Biol. 2005, 12, 677-683.

  90. 29.Generation of Valpha14 NKT cells in vitro from hematopoietic precursors residing in bone marrow and peripheral blood.

  91. Shimamura, M. Kobayashi, K. Watanabe, H. Huang, Y.-Y. Okamoto, N. Kanie, O. Goji, H. Kobayashi, M.

  92. Eur J Immunol, 2004, 34, 735-742.

  93. 30.Electrophoretically mediated reaction of glycosidase at a nanoliter scale.

  94. Kanie, Y. Kanie, O.

  95. Electrophoresis, 2003, 24,1111-1118.

  96. 31.Saturation transfer difference NMR spectroscopy to indentify ligand epitopes and binding specificities.

  97. Meyer, B. Klein, J. Mayer, M. Meinecke, R. Moller, H. Neffe, A. Schuster, O. Wulfken, J. Ding, Y. Kanie, O. Labbe, J. Palcic, M. M. Hindsgaul, O. Wagner, B. Ernst, B.

  98. Leucocyte Trafficking, Hamann, A.; Asadullah, K.; Schottelius, A. Eds., Springer, 2003, pp149-168. <Book chapter>

  99. 32.Synthetic strategies.

  100. Saotome, C. Kanie, O.

  101. Carbohydrate-based Drug Discovery, Wong C.-H. Ed., Wiley-VCH, 2003. <Book chapter>

  102. 33.An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase of influenza viruses.

  103. Guo, C.-T. Sun, X.-L. Kanie, O. Shortridge, K. F. Suzuki, T. Miyamoto, D. Hidari, K. I.-P. J. Wong, C.-H. Suzuki, Y.

  104. Glycobiology, 2002, 12, 183-190.

  105. 34.Solid-phase synthesis of oligosacharide and on-resin quantitative monitoring using gated decoupling 13C-NMR.

  106. Kanemitsu, T. Wong, C.-H. Kanie, O.

  107. J. Am. Chem. Soc., 2002, 124, 3591-3599.

  108. 35.Electrophoretically mediated microscale reaction of glycosidase: Kinetic analysis of some glycosidases at nanoliter scale.

  109. Kanie, Y. Kanie, O.

  110. Carbohydr. Res., 2002, 337, 1757-1762.

  111. 36.Design syntheses of inhibitors of glycoenzymes.

  112. Yuasa, H. Saotome, C. Kanie, O.

  113. Trends Glycosci. Glycotechnol., 2002, 14, 231-251. <REVIEW>

  114. 37.Recent developments in oligosaccharide synthesis: Tactics, solid-phase synthesis and library synthesis.

  115. Kanemitsu, T. Kanie, O.

  116. Comb. Chem. High Thrughput Screen. 2002, 5, 339-360. <REVIEW>

  117. 38.Combinatorial library of five-membered iminocyclitol and the inhibitory activities against glyco-enzymes.

  118. Saotome, C. Wong, C.-H. Kanie, O.

  119. Chem. Biol., 2001, 8, 1061-1070.

  120. 39.Carbohydrate libraries by the random glycosylation approach.

  121. Kanie, O. Hindsgaul, O.

  122. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries, Seeberger P. Ed., John Wiley & Sons Publishers, 2001, pp239-256. <Book chapter>

  123. 40.Orthogonal strategy in oligosaccharide synthesis.

  124. Kanie, O.

  125. Carbohydrates in Chemistry and Biology, Ernst, B.; Hart, G.; Sinay, P. Eds., Wiley-VCH, 2000 Vol. 1, pp407-426. <Book chapter>

  126. 41.Carbohydrate-related Libraries.

  127. Kanemitsu, T. Kanie, O.

  128. Trends Glycosci. Glycotechnol. 1999, 11, 267-276. <REVIEW>

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